As a result of the alkaloids Greater Celandine is mildly sedative and has antispasmodic action on the intestines and the gallbladder. It also stimulates bile flow. It is often used to alleviate intestinal symptoms and bile congestion. Warts can be treated by dabbing with the fresh sap several times a day.
In homeopathy formulations of Greater Celandine root are used for gallbladder and liver disorders as well as in some eye diseases. Greater Celandine is also used as a home remedy for some skin diseases.